The Use of Ampligen Alone and in Combination with Ganciclovirand Coumermycin A1 for the Treatment of Ducks Congenitally Infectedwith Duck Hepatitis B Virus
mpligen,a known immunomodulator and interferon inducer.was used alone and in conibination with other antiviral agents to treat ducks congenitally infected with duck hepatitis B virus.Theseantiviral agents included the conventional nucleotide analogue gunciclovir and the prokaryotic DNA gyrase B inhibitor coumermycin A1.When use alone,ampligen decreased the amount of serum and liverviral DNA,but had no effeet on circulating duck hepatitis B surface antigen (DHBsAg).In combination with sanciclovir,the antivir...