【摘要】 以玻碳电极为基体,制备了Nafion修饰电极,研究了非电活性阳离子药物美西律在该电极上的测定方法,将美西律加入到含电活性阳离子药物多巴胺的电解质溶液中,使多巴胺峰电流下降,峰电流的降低与美西律浓度的负对数在4×10^-6～2×10^-4mol/L范围内呈良好的线性关系。该方法的检测下限为2×10^-6mol/L,回收范围为96.1％～105.4％,相对标准偏差为2.8％（n=10）。该法用于美西律片剂的测定,获得了满意的结果。更多还原

【Abstract】 Mexiletinc is an electroactive cationic drug. This paper describes the method for determination of microamount mcxiletine with Nafion-modified glassy carbon electrode. The peak current of dopamine is decreased when mexiletine is added to an electrolyte solution containing electroactivc dopamine. There is a good linear relationship between the extent of the decrease in the peak currcntand the negative logarithmic concentration of mexiletine in the range of 4×10^-6～2×10^-4 mol/L. The detection limit of the method is 2×10^-6mol/L. The recovery is 96.1×～105.4％. and the relative standard deviation is 2.8％（n=10）. By using this method to determine mexiletine hydrochloride in tablets, satisfactory results are obtained.更多还原