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钼和高铁血红蛋白还原酶的关系:大鼠低钼食实验

STUDY ON THE RELATION BETWEEN MOLYBDENUM AND METHEMOGLOBIN REDUCTASE:LOW MOLYBDENUM DIET EXPERIMENT IN RATS

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【作者】 杨原王凡李广生康德仁

【Author】 Yang Yuan; Wang Fan; Li Guangsheng; Kang Deren(Institute of Preclinical Sciences ,Norman Bethune University of Medical Sciences,Changchun,Jilin 130021)

【机构】 白求恩医科大学应用基础医学研究所

【摘要】 用人工配制的半纯化低钼词料喂饲大鼠5周,其红细胞NADH-细胞色素b_5高铁血红蛋白还原酶(NADH-b5-MHbK)活力下降。补钼1.0和5.0mg/kg可使其活力明显上升。对低钼组、低钼补钼0.1mg/kg组和低钼补钼1.0mg/kg组大鼠红细胞NADH-b_5-MHbR活力和钼含量的相关性分析结果表明,两者呈明显正相关。结合反复失血实验结果,提出此酶可能是一种新的含钼酶或是依赖于钼的酶。

【Abstract】 olybdenum deficiency of rats was produced by low molybdenum diet.The NADH-cytochrome b5-methemoglohin reductase activity in erythrocyte was increased significantly in the rats supplemented with 1.0 and 5.0mg/kg Mo as NaMoO4 to the diet.The concentrations of molybdenum in ery-throcytes of rats of supplemented groups were significantly higher than those of low molybdenum group.The concentration of molybdenum in erythrocytes was significantly correlated with NADH-cytochrome b5-met-hemoglobin redutase activity in rats supplemented with 0.1 and 1.0 mg/kg molybdenuM. Molybdenum might be an essential component of NADH-cytochrome b5-methemoglobin reductase or the activity of this enzyme might depend on molybdenum.

【基金】 中国科学院科学基金
  • 【文献出处】 营养学报 ,ACTA NUTRIMENTA SINICA , 编辑部邮箱 ,1994年02期
  • 【分类号】R151.2
  • 【被引频次】2
  • 【下载频次】30
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