【摘要】 本实验研究了维生素Ｅ（ＶＥ）改善烧伤后免疫功能的作用，并对其作用机制进行了探讨。结果显示，小鼠１１％～１２％总体表面积（ＴＢＳＡ）全层皮肤烧伤后血、肝、脾中过氧化脂质（ＬＰＯ）水平升高、谷胱甘肽（ＧＳＨ）含量下降，淋巴细胞增殖反应、白介素一２（ＩＬ一２）生成、空斑形成细胞（ＩＪＦＣ）形成及迟发型超敏反应（ＤＴＨ）均处于抑制状态。投予ＶＥ后可防止烧伤动物体内ＬＰＯ水平、ＧＳＨ含量明显变化，免疫功能受抑制的程度也明显小于未投予组。以超氧化物歧化酶（ＳＯＤ）处理的作用与ＶＥ相同。体外实验显示，过氧化亚油酸可抑制淋巴细胞增殖反应以及ＩＬ一２产生、诱发淋巴细胞脂质过氧化、降低淋巴细胞内ＧＳＨ含量。淋巴细胞上述功能的抑制与ＬＰＯ水平密切相关；加入ＶＥ可抑制过氧化亚油酸对淋巴细胞的上述作用。提示ＶＥ可改善烧伤后免疫功能，其机制可能是通过抗氧化作用而发挥的。更多还原

【Abstract】 he benificial effect of vitamin E on immunity after burn andits me-chanism were studied,Results showed that followinga 11%～12% TBSA full-thickness skin burn in mice, the lipld peroxide(LPO) was increased andthe GSH contents of blood, liver and spleen were decrcased.Lymphocyte pro-liferation, IL-2 production. PFC formation and DTH were also depressed.Treatment with vitamin E inhibited the increase in LPO and decrease inGSH content and improved the above suppressed immune functions.SODcould exert similar effects as vitamin E.Studies in vitro also showed thatlinoieic acid hydroperoxide inhibited lymphocyte proliferation and IL一2 pro一duction, induced lipid peroxidation and decreased GSH content of the lym-phocytes. Addition of vitamin E to the ctlture inhibited the effect oflinoleic acid hydroperoxide on lymphocytes.It was postulated that vitaminEimproved immunosuppression following burn through its antioxidant effect.更多还原