【摘要】 本文研究主要钙拮抗剂对大白鼠吗啡戒断综合征的治疗效果。选用连续2d给药,催促成瘾的大鼠,给予不同药物治疗。结果表明,钙拮抗剂对大白鼠的吗啡戒断综合征有一定治疗作用。硝苯地平有效剂量为10-80mg·kg^-1,其中以20与40mg·kg^-1效果较好（P<0.01）;尼莫地平50-300 mg·kg^-1有效,以100mg·kg^-1为佳;维拉帕米20与40mg·kg^-1效果较好;硝苯地平与可乐宁合用后的治疗作用优于单独使用时的作用。更多还原

【Abstract】 In this paper,the effects of some main calcium antagonists and those combined with clonidine on the behavioural signs,naloxone)1 mg·kg-1,sc)-precipitated withdrawal syndromes,in morphine dependent rats were evaluated.First the rats were made addicted to morphine in two days,then naloxone was given to precipitate the withdrawal syndromes.All of the drugs studied) nifedipine at doses of 10-80 mg·kg-1,nimodipine 50-300 mg·kg-1 and verapamil 20-40 mg ·kg-1)were able to inhibit diarrhoea,body weight loss and other symptoms as well.The effect of combination of nifedipine with clonidine was better than either single drug.The data suggested that calcium channel inhibitors could be effective drugs in the treatment of morphine withdrawal syndromes.更多还原