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氟苯桂嗪治疗迟发性运动障碍的双盲自身对照试验
A Double-Blind Trial of Flunarizine Therapy for Tardive Dyskinesia
【摘要】 氟苯桂嗪与安慰剂双盲自身对照治疗迟发性运动障碍14例(男性11例,女性3例;平均年龄31±9岁),剂量为10mg,po,qd(?)疗程4周.以不自主运动评定量表为评定工具,按双向序贯t检验逐个观察.至第10例时便获得结论,氟苯桂嗪的疗效显著优于安慰剂.且未发现明显的不良反应.
【Abstract】 Fourteen tardive dyskinesia (M11,F3;age 31 ± 9 years)were given flunarizine or placebo in a selfcontrolled double-blind trial. Each patient took the drug 10mg,po,qd,for 4 weeks,their symptoms were assessed with AIMS before and after the treatment. These patients were observed one by one by the method of the two-sided sequential t test. While finishing the tenth patients,the results showed that flunarizine group had more significant effects than the control group. No apparent adverse reactions were noted.
【关键词】 氟苯桂嗪;
迟发性运动障碍;
精神状态判断表;
【Key words】 Flunarizine; Tardive dyskinesia; Psychiatric state rating scales;
【Key words】 Flunarizine; Tardive dyskinesia; Psychiatric state rating scales;
- 【文献出处】 药物流行病学杂志 ,Chinese Journal of Pharmaco Epiolemiology , 编辑部邮箱 ,1994年04期
- 【分类号】R969
- 【被引频次】7
- 【下载频次】23