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氟苯桂嗪治疗迟发性运动障碍的双盲自身对照试验

A Double-Blind Trial of Flunarizine Therapy for Tardive Dyskinesia

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【作者】 曾昭祥李志成于兴旺张永东曹中昌

【Author】 Zeng Zhaoxiang, Li Zhicheng, Yu Xingwang, Zhang Yongdong, Chao Zhongchang Jining Hospital for Prevention and Treatment of Psychiatric Disease, Shandong (272151)

【机构】 山东省济宁市精神病防治院!272151

【摘要】 氟苯桂嗪与安慰剂双盲自身对照治疗迟发性运动障碍14例(男性11例,女性3例;平均年龄31±9岁),剂量为10mg,po,qd(?)疗程4周.以不自主运动评定量表为评定工具,按双向序贯t检验逐个观察.至第10例时便获得结论,氟苯桂嗪的疗效显著优于安慰剂.且未发现明显的不良反应.

【Abstract】 Fourteen tardive dyskinesia (M11,F3;age 31 ± 9 years)were given flunarizine or placebo in a selfcontrolled double-blind trial. Each patient took the drug 10mg,po,qd,for 4 weeks,their symptoms were assessed with AIMS before and after the treatment. These patients were observed one by one by the method of the two-sided sequential t test. While finishing the tenth patients,the results showed that flunarizine group had more significant effects than the control group. No apparent adverse reactions were noted.

  • 【文献出处】 药物流行病学杂志 ,Chinese Journal of Pharmaco Epiolemiology , 编辑部邮箱 ,1994年04期
  • 【分类号】R969
  • 【被引频次】7
  • 【下载频次】23
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