【摘要】 研究了腺苷－磷酸（ＡＭＰ）对豚鼠离体去内皮主动脉的松弛作用。并与腺苷进行了比较，ＡＭＰ和腺苷的ＥＤ５０分别是０．１２和０．１０ｍｍｏｌ·Ｌ－１．ＡＭＰ的作用可被腺苷脱氨酶抑制剂９－赤薄醇（２－羟基－３－壬基）腺嘌呤所增强；并可被５′－核苷酸外切酶抑制剂α，β－次甲基腺苷二磷酸抑制．后者还可抑制ＡＭＰ在豚鼠主动脉中的降解约５０％～８５％。这些结果提示。ＡＭＰ的松弛作用可能与其在′－核苷酸外切酶的作用下生成的降解产物腺苷有关，而其本身的作用十分微弱。更多还原

【Abstract】 In order to investigate the mechanismof adenosine5′-monophosphate(AMP)rehxant ef-fects,do-endothelialized guinea pig thoratic aorta pre-contracted with phenylephrine was usedThe A M P-in-duced relaxations in aorta were com pared with th osecaused by adenosine. Adenosine induced coneentration-dependent relaxations in the aorta with an ED50 valueof0,1 mmol·L-1 and AMP did that with an ED50 val-ue of 0.12 mmol·L-1 comparable to that ofadenosine.AMP-induced relaxation was potentiated by ery-thro-9-(2-hydroxy-3-nonyl)adenine,an adenosinedeaminase inhibitor,while α,β-methylene adenosinediphosphate(AOPCP),an ecto-5-nucIcotidaseinhibitor,decreased AMP-induced relaxation. The con-centration of AOPCP used in this experiment inhibitedAMP degeneration in the aorta by 50% to 85%. Theseresults suggest that AMP-induced relaxation would bedue to adenosine produced through ecto-5′-nucleotidase pathway and the relaxation poteney ofAMP itself could be very weak.更多还原