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茴拉西坦治疗血管性痴呆的双盲临床试验

Double-blind clinical trial of aniracetam in treating vasculay dementia

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【作者】 洪震丁兆兰蒋雨平俞丽云翟治平

【Author】 HONGZhen;DING Zhao-Lan;JIANG Yu-Ping;YU Li-Yun;QU Zhi-Ping(Institute of Neurology,Shanghai Medical University,Shanghai 200040)

【机构】 上海医科大学神经病学研究所

【摘要】 血管性痴呆60例(男性50例,女性10例;年龄58±s7a)用茴拉西坦作双盲对照观察。治疗组和对照组(安慰剂)各30例,治疗组服茴拉西坦200mg,tid,共8WK结果:临床总有效率,治疗组83%,对照组60%(P<0.05);治疗组记忆商由69±15增至84±17(P<0.01),对照组由74±16增至80±20(P>0.05)。不良反应较轻,使用安全,可以选用。

【Abstract】 A double-blind trial of aniracetam in therapy of vascular dementia was conducted on 60 patients(M 50,F10;age 58±s 7 a),who were equally divided into treated group and control group.The aniracetam dosage was 200 mg,po,tid,for 8 wk.The total response rate of treated group was 83%,that of the control(placebo) group 60%(P<0.05).The memory quotient of treated group increased from 69± 15 to 84± 17(P<0.01),that of the control group increased from 74± 16 to 80± 20(P>0.05).Adverse reactions were mild and so it is safe to select this drug for clinical use in vascular dementia.

  • 【分类号】R969.4
  • 【被引频次】11
  • 【下载频次】87
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