【摘要】 用O₃对串珠镰刀菌素去毒处理后,对产物进行了分离纯化,并通过红外、核磁共振等分析,证明串珠镰刀菌素双键消失,四元环已打开,产物为2,3-二羟基-2,3环氧-丁二酸（3）和2-羰基-3-羟基-丁二酸（4）.以1日龄北京雏鸭为实验动物,将串珠镰刀菌素及其结构类似物方酸进行生物毒性对比试验,分别灌胃法给毒8mg/kg体重和方酸24mg/kg体重,方酸量为串珠镰刀菌素的三倍时仍无毒性,说明串珠镰刀菌素结构中的H对其毒性起关键作用.这在国内外尚属首次报道.更多还原

【Abstract】 Moniliformin is highly toxic to animals. It can be detoxified by treating with Ozone (O3). The structure of moniliformin treated with O3 was analysed by means of IR and NMR spectrum etc. It was proved that the double bond was disappeared and the 4-C ring structure was opened. The structure of the two products are 1, 2-dihydroxy-l ,2-di-carboxyl-epoxyethane and 2-carbonyl-3-hydroxy-dibutyric acid. The experiment of toxi-city comparison between moniliformin and its analogous material squaric acid was made using one-day age Beijing Ducklings by oral applying both medicines at dosage of 8mg/ kg and 24mg/kg body weight separately. The result showed that squaric acid had no toxic to animals though its dosage was as three times as that of moniliformin. Author concluded that H in moniliformin is the key factor of its toxicity.更多还原