【摘要】 阻断犬冠脉左前降支90min后再灌注60min，发现较持续缺血150min其缺血区细胞内Ca²⁺、Na⁺增加，K⁺、Mg²⁺显著降低。室性心律失常发生率高。而在心肌缺血45min时经静脉给予穿心莲提取液，较对照组缺血区细胞内Ca²⁺降低（P＜0.05），Na⁺明显降低、K⁺显著升高（P＜0.01），Mg²⁺增加（P＜0.05）。室性心律失常发生率及严重程度较低。说明穿心莲提取液可以阻止心肌缺血─再灌注过程中细胞内Na⁺、Ca²⁺增加，K+、Mg²⁺丢失。这可能是其减少再灌注性心律失常的重要机制之一。更多还原

【Abstract】 The intracellular Ca²⁺, Na⁺ were increased,K⁺ and Mg²⁺ decreased markedly in ischemic area of dogs undergoing left anterior descending coronary artery（LAD）ligation for 90 min and subsequent reperfusion for 60 min,as compared with sustained ischemia for 150 min.The occurrence rate of ventricular arrhythmia was high.Whereas in group pretreated with APN,in comparison with control group,the Ca²⁺in relevant area was decreased（P＜0.05）,Na⁺ markedly decreased,K⁺ significantly increased（P＜0.01）,Mg²⁺ increased（P＜0.05）.The rate and grade of ventricular arrhythmia were rarer and milder. These data suggest that APN may prevent the intramyocardial increase of Na⁺ Ca²⁺ and the 1oss of K⁺,Mg²⁺and it may explain the basic mechanism in decreasing the reperfusion arrhythmia.更多还原