【摘要】 探讨了卡介苗（ＢＣＧ）对象兔系膜增殖性肾炎（ＭｓＰＧＮ）模型的保护作用及其机理。２０只家兔随机分为Ａ，Ｂ，Ｃ三组，Ａ，Ｂ两组注射小牛血清白蛋白（ＢＳＡ）建立ＭｓＰＧＮ模地；Ｃ组作为正常对照。在静注ＢＳＡ３周前，Ａ组先注射ＢＣＧ，Ｂ组注射等渗盐水，于第１０周结束实验。结果：Ａ组循环免疫复合物、肾小球细胞数、ｌｇＧ沉积程度比Ｂ组明显减少（Ｐ＜０．０１），光镜和电镜下Ａ组的病变也明显较轻，而Ｂ组电子致密物较多。刀豆素－Ａ诱导的Ｔ淋巴细胞转化试验Ａ组较Ｂ组增强（Ｐ＜０．０５）。Ａ，Ｂ两组２４ｈ尿蛋肉、血肌酐和抗ＢＳＡ抗体滴度差异不明显。结果表明ＢＣＧ能促进ＣＩＣ清除，使ＩＣ在小球沉积减少，减轻小球系膜增殖性炎症，同时还能增强Ｔ细胞淋转功能。其保护机理可能通过增强单核巨噬细胞系统吞噬功能和抑制性Ｔ细胞（Ｔｓ）功能实现。更多还原

【Abstract】 his study was aimed at the protective rule of BCG on the rabbit model of mesangial proliferative glomerulonephritis(MsPGN) and its mechanism. Twenty rabbits were divided into 3 groups at random.Group C(n=6) was taken as a normal control, group A and B(n=7 each)were MsPGN models,which were the modified models of chronic serum GN induced by BSA intravenous injection for 6 weeks, BCG and NS was given intravenously to group A and B respectively 3 weeks prior to the injection of BSA and twice a week for the first six weeks,and then once a week for four weeks, The results showed that the CIC levels,the glomerular IgG deposits and the cell counts per glomerulus in group A were significantly less than that in group B ,but there was no significant diference between group A and C.The corresponding pothologic findings , whether examined by LM or by EM, were much lighter in group A;group A had a higher concavalin-A(Con-A ) stimulated T lymphocyte transformation (mainly to supressive T cells)than group B did.All these evidence indicated that BCG could accelarate the clearance of CIC ,reduce the IC deposite in glomeruli,mitigate the pathological changes,and strengthen the Con-A stimulated T lymphocyte transfor-mation。It is concluded that BCG could play a protective role on the rabbit model of MsPGN,which may be obtained by strengthening the activity of MPS so as to reduce the IC deposits in glomeruli and of supressive T cells, thus inhibit the antibody synthesis.更多还原