【摘要】 最小临床承认疗效差量是临床试验的一个基本参数,但未受到广泛注意。本文回顾其统计学定义,提出其临床定义,将其用于临床试验结果的解释,构成四分结果模式。以此取代传统的二分结果模式,提高了药物疗效评价的精确性。附有工作实例说明其使用方法更多还原

【Abstract】 Minimal clinically relevant therapeutic difference is a basic parameter in clinical trials, but has not been widely noticed. In this paper, we review its statistical definition, propose its clinical definition,’use it in interpreting the results of clinical trials, and construct the quadripartite-result modality. The precision of assessing the efficacy of drugs is heightened by using this modality instead of the traditional dichotomous result modality. A worked example illustrates the methodology.更多还原