【摘要】 一次给药后,不少药物的血浆浓度一时间曲线可出现双峰或多峰,肠肝循环和经胃肠道吸收的非齐性被认为是最可能的机制。我们认为,在口服给药的情况下,同时存在这两种机制是完全可能的。本文就这一复合机制提出相应的药动学模型及生物利用度计算方法,并通过模拟说明其应用价值。更多还原

【Abstract】 The plasma concentration- time curves after single dosing for many drugs may appear double or multiple peaks. The enterohepatic circulation (EHC) and unhomoge-nous absorption via gastrointestinal (GI) tract were considered most possible mechanisms. In the case of oral administration, the two mechanisms existing simultaneously is reasonable -ly possible. On the basis of the consideration, we propose a pharmacokinetic model and a calculation method of bioavailability. The results of simulation illustrate the application value of the model and method.更多还原