【摘要】 给大鼠以干扰素（ＩＦＮ－Ａ），卡介苗（ＢＣＧ）或两者联用，以墨汁吞噬实验和溶菌酶免疫组织化学法显示肝枯否细胞（ＫＣ），以图象分析系统测定ＫＣ的数量和面积；同时进行外周血非特异性酸性酯酶（ＡＮＡＥ）阳性淋巴细胞计数。结果显示：ＩＦＮ－Ａ、ＢＣＧ或两者联用后，使溶菌酶阳性和吞噬墨汁的ＫＣ数增多，尤以肝小叶周边带为显著；ＫＣ面积明显增大；外周血ＡＮＡＥ阳性淋巴细胞增多，尤以“弥散型”淋巴细胞增多较显著。上述作用中ＢＣＧ较ＩＦＮＡ明显，尤以两者联用的效果最强。是免疫制剂增强ＫＣ抗肝癌细胞作用有关的细胞学机制。更多还原

【Abstract】 Rats were given IFN-A,BCG,or IFN-A+BCG respectively, Kupffer cells (KC) were shown by means of ink-phagocytosis and lysozyme immunohistochemical staining,the number and areas of KC were assayed using image analysis,and the percent of alpha-naphthyl acetate estase (ANAE) positive lymphocytes in blood was estimated.Results showed that the number of lysozyme positive and ink-phagoeyttic KC increased as compared with that of controls,especially in peripheral zone of hepatic lobule; the mean area of lysozyme positive KC was larger than that of controls; the percent of ANAE positive lymphocytes of treated rats was increased, and the percent of scattered ANAE positive lymphocytes increased obviously,The effect of BCG was stronger than that of IFN-A,and IFN-A+BOG exhibited the strongest effect.The above mentioned results may related to the mechanisms of immuune stimulants which can enhance anti-hepatoma effects of KC.更多还原