【摘要】 用分离分析方法对１６１个原发性高血压患者核心家系进行了遗传异质性分析。结果表明原发性高血压存在遗传异质性，有些家系为常染色体显性遗传，外显不全，外显率为８８．１％；有些家系为散发的。本组家系中，常染色体显性外显不全家系占８２．８％，散发家系占１７．１２％。更多还原

【Abstract】 Segregation analysis was performed on 161 nuclear families ascertained through 95 index patients with essential hypertension. The frequent vertical transmission and high segregation ratio suggest an autosomal dominant inheritance in the familial essential hypertension. Affected offsprings with one affected parent were compatible with autosomal dominance inheritance of incomplete penetrance (88. 1%). Affected offsprings from normal by normal matings were largely due to autosomal dominant inheritance,with 23.4% of sporadic cases. The overall genetic constitution is sporadic cases 17. 2%, autosomal dominance 82. 8%.更多还原