【摘要】 本文报道了吡喹酮对日本血吸虫病人血清循环抗原(CAg)的激升效应。病人分别在经40mg、20mg、10mg/kg 体重剂量的吡喹酮作用后1、3、6天以单克隆抗体 Dot-ELISA(McAb-Dot-ELISA)检测血清循环抗原,结果显示,其检出水平显著高于吡喹酮作用前,平均检出滴度提高1～4倍,阴性样本经吡喹酮激惹后均转为阳性。此结果提示,在经吡喹酮激惹后短时间内,病人血清的 CAg 水平有一个明显的升高过程,此举对于提高慢性、低感染度血吸虫病人的血清 CAg 检出水平具有一定的意义。更多还原

【Abstract】 The serum CAg levels of chronic schistosomiasis patients was detected using McAb-Dot-ELISA method before and 1,3 and 6 days after taking orally different doses of praziquantel.The results showed that the serum CAg levels and its positive detection rate could be raised significantly,the mean titer of serum CAg raised by 1-4 times after taking praziquantel.It suggested preliminarily that praziquantel has the effect on stimulating schistosoma adult worms to secrete CAg.The significance of detecting serum CAg of the patients with chronic schistosomiasis with low infectiosity by taking orally praziquantel was discussed in this paper.更多还原