【摘要】 肝素类(?)阴离子化合物能与鱼精蛋白特异结合,破坏精子核中鱼精蛋白-DNA复合结构,使精子核膨胀.本研究利用这一特性对小鼠睾丸注射大刘量肝素后,观察精子形态,活动度及总计数等常规指标的变化,以确定肝素对鱼精蛋白,对精子生成及成熟后的含量,研究结果证明,小鼠睾丸注射大剂量肝素后,可以明显减少核内鱼精蛋白的影响,畸形率增加,活动度在高剂量组虽有降低.但不明显,也无剂量-反应关系,总计数无明显变化,结果认为,肝素影响鱼精蛋白的核内含量变化,进而影响其精子形态的变化,而导致生育力的下降.更多还原

【Abstract】 The effect of heparin on sperm normal shape, total count, motility and concentration of protamine was studied. The results showed that the concentration was decreased after injecting heparin to mouse testes. A good relation ship was observed between the dose of heparin and the concentration of prota mine(r =-0.89) and the abnormal sperm shape (r = 0.74). There is no such relationship between the dose of heparin and total sperm count and motility. It shows that heparin has an effect on protamine concentration and then effect the normal sperm shape. These may be the reason that causes infertility.更多还原