【摘要】 对10例原发性局灶节段性肾小球硬化症患儿采用强的松、6-硫鸟嘌呤(6-TG)和雷公藤多甙(T_Ⅱ)治疗,结果仅1例对激素有反应,但仍进入氮质血症期;余9例患儿中,6例接受T~Ⅱ(1mg/kg·d)治疗,4例完全缓解,2例无效应且氮质血症无改善;另3例患儿接受6-TG(2mg/kg·d)治疗均获持续缓解。此外研究表明血尿、氮质血症、肾小球系膜增生、小管间质改变和透明样变肾小球大于50％,提示治疗效果差。更多还原

【Abstract】 Ten children with idiopathic focal segmentai glomerulosclerosis (FSGS) were treated with predinsone, 6-thiogunine (6-TG) and polyglucoside of Tripterygium wii-fordii Hook f. (TII). Data showed that only one patient responded to steroid, but still progressed to azotemic stage. Among other 9 children who did not respond to steroid, 6were then treated with Til(1 mg/kg·d). 3 with 6-TG (2 mg/kg·d). Four patients recievingTll were in compiete remission, 2 recieving T u were still in nephrotic state and in azotemic stage. Three patients recieving 6-TG all got persistent remission. It was also found that hematuria, azotemia, glomerular mesangial proiferation, tubulointerstitiai changes and glomerular hyalinosis more than 50% were poor indices of therapeutic result.更多还原