【摘要】 对24只犰狳接种麻风菌、感染11个月后摘除其右眼,然后分为二组,各进行DDS或MDT治疗。治疗两个月后处死动物,解剖,取出左眼、内脏和皮肤的麻风瘤。分析动物感染的情况、麻风瘤的病变。以及治疗前后两只眼之病变的差别。发现在用几种治疗后,动物肝脾内的含菌量,均与未治疗的两个对照动物的类似,都在每克组织内有10~6个菌的水平。治疗前后其麻风瘤的大小并无具有统计意义的差别。在所有动物中,有8只动物的瞬膜和眼睑病变属于重度,有4只的瞬膜和限睑内有明显的泡沫细胞浸润,而且在炎性细胞间见到抗酸菌。眼内组织的变化都很轻微;除一例外,在眼内都没有找到抗酸菌。这使人考虑到麻风眼内病变也有可能经由外眼局部病变传播而来。因此,在用药物全身治疗麻风时,如果在眼局部加用药物,或许能阴止和减轻麻风眼病的发生和发展。更多还原

【Abstract】 Twenty four armadillos were inoculated with M.leprae.Eleven months after the inoculation,the right eyes of the animals were extracted.The animals then were divided into two groups for treatment,one group with MDT and the other with DDS.Two months later the animals were sacrificed.The histological changes of their eyes,the lepromas at the sites of the inoculation and the viscera were studied.It was found that the contents of the bacilli in the nver or spleen of the animals in both the groups,were similar.It seems that the sizes of the lepromas before and after treatment were of no statistically significant difference.The inflammatory reaction of the nictating membranes and eyelids in eight animals were quite severe,and lepra cell infiltration and acid fast bacilli were found in these tissues of four animals.Intraocular inflammatory cell trifiltrations in these animals all were mild,and no acid fast bacilli was found within the eyes,except in one.In view of these findings,it might be suggestive that some intraocular leprosy could be the result of spreading of infection from the lesions of the periocular tissues.If so,local drug treatment in the eye in addition to the general treatment in the patients would be useful in preventing or minimizing the intraocular lesions.更多还原