【摘要】 报道了烟酰胺预防丁哌卡因中毒的动物实验研究。烟酰胺降低注射丁哌卡因引起的小鼠死亡率，提高麻醉大鼠输注丁哌卡因的耐受性，减少室性心律失常的发生率，减轻心电图改变。结果提示，烟酰胺对丁哌卡因中毒确有保护作用，这可能与其能抗心律失常、改善心功能有关．更多还原

【Abstract】 he protoctive effects of nicotinamide on bupivacaine intoxication were studied in rats。It was found that themorbidity of ventricular arrhythmia and mortality induced by bupivacaine were significantly decreased in rats pre-treated with nicotinamide,Its protective effects may be related to the antiarrhythmiac effect of nicotinamide。更多还原