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流式细胞术对肾肿瘤和膀胱肿瘤患者预后判断的价值

Flow cytometric analysis for prognosis in the tumour of the bladder and kidney

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【作者】 苗文隆李喆张晓云

【Author】 Miao Wenlong Zhang Xiaoyun Li Zhe(Department of Urology,the 1st Affiliated Hospitalof Zhangjiakou Medical College,Zhangjiakou)

【机构】 河北省张家口医学院第一附属医院泌尿外科!075000硕士研究生河北省张家口医学院生理教研组河北省张家口医学院第一附属医院泌尿外科!057000导师

【摘要】 报告43例肾肿瘤和61例膀胱肿瘤石蜡包埋组织流式细胞术(FCM)检测结果:脱氧核糖核酸指数、S期细胞比例和细胞增殖指数在膀胱肿瘤和肾肿瘤间以及不同组织来源肾肿瘤间(肾细胞性、移行细胞性、胚胎性和结缔组织性)差别无显著性,而与病人预后关系密切;在膀胱肿瘤和肾肿瘤分级和分期的基础上,FCM检测可提供更多有关预后信息。

【Abstract】 Ploidy and cell-cycle stage were determined by flow cytometry (FCM) in 43 paraffin embeded specimens tumours of the kidney and 61 paraffin embeded specimens tumours of the bladder. There were no significant differences in the deoxyribonucleic acid index (DI) ,the percentage of S-phase cells and proliferative index (PI) between the tumours of the kidney and the bladder , and among the tumours of the kidney originating in parenchymatous, transitional , embryonic and connective tissues .regardless of tissular origin ( P >0. 1). The results of FCM was statistically and significantly associated with clinical outcome ( P <0. 05),providing additional information in tumours originating in urinary apparatus for prognosis beyond that obtained from tumour grade and stage.

【关键词】 膀胱肿瘤肾肿瘤流动细胞计数
  • 【文献出处】 临床泌尿外科杂志 ,Journal of Clinaical Urology , 编辑部邮箱 ,1994年05期
  • 【分类号】R737.1
  • 【下载频次】28
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