【摘要】 通过对大鼠急性出血坏死性胰腺炎（ＡＨＮＰ）动物模型的观察发现：血、肝、心、肺、脑、肾等组织内丙二醛均明显高于正常对照组（Ｐ＜０．０１～０．０５）；胰组织内丙二醛与上述各组织内丙二醛含量呈正相关（ｒ＝０．５２７～０．７８９，Ｐ＜０．００１），与血红细胞超氧化物歧化酶活性呈明显负相关（ｒ＝－０．７６２Ｐ＜０．００１），同时各器官在病理形态上均有不同程度的改变．研究表明，氧自由基在ＡＨＮＰ及其胰外器官损伤过程中起着重要作用，为临床胰腺炎的研究提供了一定的理论基础和实验依据。更多还原

【Abstract】 From a model of acute hemorrhagic necrotizing pancreatitis wistar rat observation,we discover that MDA in serum,hepatic,pulmonary,cardia, cerebral,renal tissues is obviously higher than that of the control group(P<0.01～0.05).MDA in pancreatic tissue is positively correlated with that of other tissues (r=0.527～0.789, P< 0.00l) and negatively correlated with RBC SOD activity(r=-0.762,P<0.00l).Every organ has different pathologic change. The study indicates that oxygen-derived free radicals play on importantrole in AHNP and extra-pancreatic organs injury. This study offers some theoretic ideas andexperimental data for the research of clinical acute pancreatitis.更多还原