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丙氨酸锗抗肿瘤活性及免疫效应

ANTITUMOR ACTIVITY AND IMMUNOLOGICAL EFFECT OF ALANINE-GERMANIUM

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【作者】 葛学美赵法郭俊生陈洪章朱平民吉玉申

【Author】 GeXuemei;ZhaoFaJi;GuoJunsheng;ChengHongzhang;ZhuPingming;JiYushen(Department of Army Hygiene,Second Military Medical University,Shanghai)

【机构】 第二军医大学军队卫生教研室

【摘要】 为探讨丙氨酸锗的抗肿瘤活性及免疫效应,本文进行了两个瘤株的抗肿瘤实验和免疫实验。结果表明:丙氨酸锗能明显延长移植H_(22)肝癌腹水型小鼠的生存时间,抑制S_(180)肉瘤生长,提高T淋巴细胞 ̄3H-TdR掺入指数,增强单核吞噬细胞吞噬功能。提示丙氨酸锗具有抗肿瘤活性,其抗肿瘤活性可能是通过提高机体免疫机能实现的。

【Abstract】 n order to study the antitumor activity and immunological effect ofalanine-germanium,the tests had been made,The results showed thatalanine-germanium could obviously extend the survival time of mice with H22ascites tumor and retard the growth of sarcoma 180.The stimulating index( ̄3H-TdR) of T-cell stimulated by ConA of alanine-germanium group wasmuch higher than that of the control,It also exhibited obvious enhancementof corrected phagocytici ndex of the mononuclear phagocytes in groups ofdifferent doses.These results indicated that alanine-germanium had anti-tumor activity and this effect was realized probably through the route ofenhancement of immunopotency.

【关键词】 丙氨酸锗肿瘤免疫
【Key words】 alanine-germaniumtumorimmune
  • 【文献出处】 解放军预防医学杂志 ,JOURNAL OF PREVENTIVE MEDICINE OF CHINESE PEOPLE’S LIBERATION ARMY , 编辑部邮箱 ,1994年05期
  • 【分类号】R730.53
  • 【下载频次】35
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