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急性重复缺氧对小鼠脑脂质过氧化水平的影响

Effects of Acute Repetitive Hypoxia on Lipid Peroxide Levels in Mouse Brain

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【作者】 徐瑞兴周玉兰吕国蔚

【Author】 Xu Rui xiug Zhou Yulan Lu Guowei(Department of chemistry and and neurobiology,capital institute of medicine,100054 Beijhg)

【机构】 首都医学院化学教研室

【摘要】 采用荧光法测定急性重复缺氧小鼠脑中的脂质过氧化水平,发现经一次、二次重复缺氧的小鼠与对照组之间存在统计学差异,且脂质过氧化水平随重复次数的增加而提高。但四次重复缺氧时,则又呈现向对照组水平回落的趋势。

【Abstract】 he levels of lipid peroxides in the mouse bisin were determined by thiobar- bituric acid fluorophotometry during acute repeatcd exposure to hypoxia. The 1 evcl of lipoperoxide was found to be increasad as the hypxia exposure repeated for 1 ahd 2 runs. Significant differences were shown between the control group and experimental group exposed to hypoxia for 1 run and 2 runs. No sigificant diffc- rencc in the lipoperoxide level was seen between control group and experimental gr oup expoxed to hypoxia for 4 runs.suggesting some adaptive changes occur in the brain of hypoxia rsistane mice.

  • 【文献出处】 基础医学与临床 ,BASIC MEDICAL SCIENCES AND CLINICS , 编辑部邮箱 ,1994年06期
  • 【分类号】R364.4
  • 【被引频次】7
  • 【下载频次】31
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