【摘要】 不饱和内酯二萜化合物8R23,9R221,9R6222,10R221,H1105直接杀死艾氏腹水瘤细胞的IC₅₀分别为18.6,85.8,67.8,34.9,3.05μmol/l,对S₁₈₀腹水瘤细胞的IC₅₀分别为10.7,44.4,30.9,9.95和2.4μmol/l。对肿瘤细胞具有显著作用的8R23及10R221化合物还能显著升高cAMP水平;8R23,10R221,H1105可明显抑制癌细胞的DNA合成。结果显示,这几种不饱和内酯二萜化合物均具有明显的体外抗肿瘤作用,其机制有所差别。更多还原

【Abstract】 The compounds (8R23, 9R221 , 9R6222, 10R221 , H1105) extracted from the soft coral, with unsaturated lactone, showed antitumor effect on EAT, IC50 was 18. 6,85. 8,67. 8,3d. 9, 3.05umol. L-1, respectively; IC50 on S180 was 10. 7,44. 4,30. 9,9. 95,2. 4umol. L-1, respectively. 8R23, 10R221 obviously increased the level of cAMP in the EAT cell. 8R23, 10R221 , III 105 also inhibited DNA synthesis of the EAT cell.These results indicated that these compounds might have antitumor effect, but the mechanism was unknown.更多还原