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联合应用IL-2治疗恶性肿瘤疗效分析

Analysis of Therapeutic Effects of Patients with Advanced Malignant Tumor by Combination Administration of IL-2

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【作者】 张明智周云蒿黎宋敏

【Author】 Zhang Mingzhi; et al(Department Of Oncology, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450052)

【机构】 河南医科大学一附院肿瘤科

【摘要】 为了探索肿瘤生物治疗的方式和方法,我们应用白细胞介素Ⅱ(IL-2)与干扰素(IFN-α)或香菇多糖联合应用治疗晚期恶性肿瘤11例。每个病人均应用IL—21~15×104u/天,肌肉注射,总量2~28.5×104u;联用IFN-α6例,1~9×106u/天,肌肉注射,总量4~114×106u;联用香菇多糖5例,1~2mg/次,总量12~16mg。总客观有效率为22%。治疗后患者生存质量提高,一些病人的免疫指标有不同程度的改善。从癌症治疗的战略上讲,生物治疗可使病人长远受益。

【Abstract】 Eleven patients with advanced malignant tumor were treated with interleukin-2(IL-2) and either alpha-interferon (IFN-α),or lentinan. All of the patients received IL-2 at a dose of 1~15×104u/d (total dose 2~28. 5×105u)by intramuscular injection in conjunction with either IFN-α(six patients )at a dose of 1~9 106u/d (total dose 4~114×106u)by intramuscular injection,or lentinan(five patients )at a dose of 1~2mg/次 (total dose 12~16mg) by intravenous infusion. Total objective response was 22%. After treatment the patients’ survival quality was raised and some patients’ immunological assessments were improved. In view of treatment strategy of malignant tumor, biological treatment can make patients beneficial for a long time.

【关键词】 IL-2生物治疗晚期恶性肿瘤
【Key words】 IL-2biological treatmentadvanced malignant tumor
  • 【文献出处】 河南肿瘤学杂志 ,HENAN JOURNAL OF ONCOLOGY , 编辑部邮箱 ,1994年04期
  • 【分类号】R730.5
  • 【下载频次】28
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