【摘要】 用荧光分光光度计的方法研究了二甲苯胺噻唑（静松灵）对乙酰胆碱（ＡＣＨ）的影响．肌注２．５ｍｇ／ｋｇ该药后，血液及脑脊液中ＡＣＨ浓度呈上升趋势，于２．５小时达峰值．血液ＡＣＨ由０时７．９６５±０．４１８ｎｇ／ｍｌ增至２．５小时的４３．９３９±１．３０７ｎｇ／ｍｌ（ｎ＝５，Ｐ＜０．０１），ＡＣＨ浓度增加了４．５倍；脑脊液ＡＣＨ则由０时的１２．７２２±１．３４７ｎｇ／ｍｌ增至７１．９５４±２．２５７ｎｇ／ｍｌ（ｎ＝４，Ｐ＜０．０１）增加了４．７倍，差异极显著．血液与脑脊液中ＡＣＨ浓度变化呈正相关（ｒ＝０．９４４）．更多还原

【Abstract】 Studies the effect of xylazole on acetylcholine(ACH) with spectrophoto fluorometer.CsF and plasma ACH levels increased significantly as compared with those of contrds after im.xylazole.Aincrease of more than 4.5 times was observed at 2.5 hours compared with time zero (time zero=7.965±0.418ng/ml;2.5hours=43.939±1 .307ng/ml n=5, p<0.001) in plasma, About 4.7￣ fold increase ocurred at 2.5 hours compared to time zero ltime zero = 12.722±1.347ng/ml,2.5hours = 71.954±2.257ng/ml, n=4, P<0.01) in csf. ACH lenels between csF and plasma are positive and significant correlation(r=0.944).更多还原