【摘要】 用放射免疫法测定了２０例高原肺水肿（ＨＡＰＥ）患者血清内源性洋地黄样因子（ＥＤＦ）浓度，并与１４例刚入高原健康人对比，结果表明：多数（１５／２０）患者血清ＥＤＦ浓度明显增高（Ｐ＜０．０５），少数患者（５／２０）明显降低（Ｐ＜０．０５）而保持平原值水平；ＥＤＦ浓度与ＰａＯ＿２、左心功能的敏感指标ＰＥＰ／ＬＶＥＴ比值呈明显负相关。对其在ＨＡＰＥ的发生发展中的作用进行了初步探讨。更多还原

【Abstract】 etermination of serum endogenous digitalis─Like factor(EDF) concentration was carriedout in 20 patients with high altitude Pulmonary edema(HAPE)by radioimmunoassay in altitude3658m. The results showed that concentration of serum EDF in patients with HAPE was signifi-cantly rise(15/20)or lower(5/20)than in mormal subjects just getted into altitude 3 658m(P<0.05～0.01).The lowering of serum EDF concentration was signifiicantly negatively correlatedwith the severity of heart function,r=-0.6832,P<0. 01,and relationship of EDF and their ef-fects in pathogenesis and monitoring of HAPE are further discussed and evaluated.更多还原