【摘要】 本文进行了分别由三个厂家生产的法莫替丁在１０例正常志愿者中的药代动力学研究。１０例正常志愿者交叉口服由温州，青岛及国外生产的２片法莫替丁片（每片２０ｍｇ），用ＨＰＬＣ法测定法莫替丁的血浆浓度和回收率。研究结果表明：药代动力学符合开放性二室模型。主要药代动力学参数如下：温州组：Ｔ_ｐｅａｋ＝２．０１±０．３４ｈ，Ｃ_ｍａｘ＝１６６．１０±４２．９６μｇ·ｈ^－１·Ｌ^－１，Ｔ_１／２β＝２．３８±０．５２ｈ，ＣＬｒ＝１２．０６±２．１８ｌ／ｈ，ＡＵＣ＝９２０．２０±１３０．００μｇｈ^－１·Ｌ^－１；青岛组：Ｔ_ｐｅａｋ＝１．８７±０．３４ｈ，Ｃ_ｍａｘ＝１７７．０８±３３．３８μｇ·ｈ^－１·Ｌ^－１，Ｔ_１／２β＝２．６４±０．６９ｈ，ＣＬｒ＝１２．０７±２．２５ｌ／ｈ，ＡＵＣ＝９３７．２３±１１７．００μｇ·ｈ^－１·Ｌ^－１；国外组：Ｔ_ｐｅａｋ＝１．９４±０．５８ｈ，Ｃ_ｍａｘ＝１６５．８０±３８．１３μｇ／１，Ｔ_１／２β＝２．５１±０．６１ｈ．Ｃｌｒ＝１２．０４±２，４２１／ｈ，ＡＵＣ＝８９４．３３±１３０．７３μｇ·ｈ^－１·Ｌ^－１。更多还原

【Abstract】 The pharmacokinetics of famotidine produced by Wenzhou,Qingdao,foreign pharmaceutica respectively was studied in ten healthy male volunteers after oral administration of two tablets（40mg）.Famotidine concentration was determined by HPLC.The plasma level-time curve of famotidine was fitted to two-compartment open model.The pharmacokinetic parameters of famotidine are as follows:Wenzhou（T1）:T_peak=2.01±0.34h.C_max=166. 10±42.96μg/l,AUC=920.20±130,00μg·h￣（-1）·L￣（-1）,T_1/2β=2.38±0.52h,Clr=12.06±2.18 l/h; Qingdao（T2）:Tpeak=1.87±0.34h,C_max=177.08±33.38 μg/1. AUC=937. 23±117.00μg·h￣（-1）·L￣（-1）,T1/2β=2. 64±0. 69h.Clr=12.07±2.25 l/h; Foreign（T3）:T_peak=1.94±0.58h.C_max=165.80±38.13 μg/l.AUC=894.33±130.73μg·h￣（-）·L￣（-1）,T_1/2β=2.51±0.61h,Clr=12.04±2.42 l/h;relative bioavailability:F T1/T2（%） = 98.35±10.88%;F T1/T3（%）=102.95±13.35%更多还原