【摘要】 以奎宁和番木鳖碱为拆分试剂，成功地拆分了外消旋的Ｏ－甲基Ｏ－苯基硫代磷酸２。拆分的酸（＋）－２和（－）－２在甲醇钠存在下与溴丙烷反应，分别得到旋光活性的（－）－Ｏ－甲基Ｓ－丙基Ｏ－苯基硫代磷酸酯１和（＋）－１。通过化学相关法确定了１的绝对构型为（－）－（Ｓ）和（＋）－（Ｒ）。更多还原

【Abstract】 acemic O-methyl O-phenyl thiophosphoric acid 2 has been successfully resolved through its quinine and brucine salts in methanol solution by the fractional crystallization method. The optically active acids,( +)-2 and( )-2,react with propyl bromide in the presence of EtONa/EtOH to give(-)-O-methyl S-propyl O-phenyl phosphorothiolate 1 and(+)-1,respectively.The absolute configuration of the optically active 1 has been established as( )-(S)and(+)-( R) by the chemical correlation method.更多还原