【摘要】 合成了３种主链含己烷雌酚的生物可降解的聚用酸酯，结构经ＩＲ、~１ＨＮＭＲ和元素分析鉴定。通过水接触角的测定研究了聚合物的亲水─疏水性能。以ｐＨ值变化表征了聚合物的体外水解速率．初步的体外实验表明，此类聚磷酸酯具有较好的体外抗艾氏腹水癌活性．更多还原

【Abstract】 Three biodegradable polyphosphate esters were synthesized by polycondensation of hexestrol with dichlorophosphoric acid ethyl ester,dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester.The structures of these polymers were confirmed by IR,1H NMR and elementary analysis.The release testing was carried out in different pH media.The in vitro antitumor activity data showed that this kind of polyphosphate ester as polymeric prodrugs exhibits a good antitumor activity against EAC cells.更多还原