【摘要】 短肽５－氟尿嘧啶前体药物的合成及其抗肿瘤活性研究罗毅，卓仁禧，范昌烈（武汉大学化学系，武汉，４３００７２）关键词氨基酸，短肽，５－氟尿嘧啶，抗肿瘤活性５－氟尿嘧啶（５－ＦＵ）是一种治疗癌症的广谱性抗代谢药物，但由于其毒副作用较大，从而限制了它在临床上...更多还原

【Abstract】 Six hydrophobic peptidyl 5-FU prodrugs and four amino acid derivatives of 5-FU (Val, Leu, Phe, Gly) were synthesized. All of these new compounds were characterized by UV, IR,￣1H NMR and elementary analysis. The antitumor activity of these compounds were tested against EAC cells in vitro.更多还原