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淋巴因子相应靶细胞的小剂量辐射效应

EFFECT OF LOW DOSE RADIATION ON THE TARGET CELLS TO LYMPHOKINES RELATED

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【作者】 刘伟宏李修义刘树铮

【Author】 Liu Weihong; Li Xiuyi; Liu Shuzheng(Department of RadiaMon Biology, Norman Bethune University of Medical Scinces,Changchun, 130021)

【机构】 白求恩医科大学放射生物教研室

【摘要】 观察了单次小剂量X射线全身照射后C57BL/6小鼠胸腺细胞IL-1反应性和脾细胞IL-2反应性的变化。发现在100mGy以内的小剂量照射后,整个胸腺和脾脏的细胞数趋于增多,胸腺细胞对IL-1的反应性和牌细胞对IL-2的反应性趋于增强,体外照射IL-2依赖株CTLL-2细胞亦出现同样的反应趋势,但统计学处理与对照组比较均无明显差异。

【Abstract】 The changes of reactivities of thymocyte to IL-1 and splenocyte to IL-2 were studied in C 57 BL/6 mice after whole body X-irradiation with low doses. It was found that the number of thymocyte and splenocyte was increased,the reactivities of thymocyte to IL-1 and splenocyte to IL-2 also showed a tendency to increase after X-irradiation with low doses below 100 mGy, but the increase was statisticaly not significant. There was a same effect of low dese radiation on the CTLL-2, growing dependent on IL-2, irradiated in vitro.

【基金】 国家自然科学基金
  • 【文献出处】 辐射研究与辐射工艺学报 ,Journal of Radiation Research and Radiation Processing , 编辑部邮箱 ,1994年02期
  • 【分类号】Q691
  • 【下载频次】29
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