【摘要】 用硫代巴比妥酸反应的荧光分析法和超微弱发光法检测了十种含—CH₂CH₂N（CH₃或C₂H₅）.基团的临床应用药物对辐照膜脂过氧化的影响,结果表明绝大多数被试药物有较强的抗膜脂过氧化作用.此外,黄嘌吟-黄嘌吟氧化酶系统的实验表明部分被试药物具有较强的减少O₂的能力.对药物结构与其抗膜脂过氧化效率之间的关系进行了初步探讨,结果提示:具有多元环及一正电中心的—CH₂CH₂N（CH₃或C₂H₅）₂化合物可能多为膜脂过氧化的抑制物.更多还原

【Abstract】 The present study examines the inhibitory efficiency on lipid peroxidation(LP) of ten-CH2CH2N(CH3 or C2H5)2-containing drugs. Data obtained from TBA-test and ultraweak chemiluminescence indicate that most of the drugs tested hold a strong anti-LP effect. Meanwhile,esperiments with a model system of xanthine and xanthine oxidase also show part of these drugs have efficient capacity of O2-scavenging. The analysis of relations between drug-induced inhibition of LP and drug structure suggests that,apart from the above group,a polyatomic ring and an eletropositive center may also play an inportant role in lipid peroxidation inhibition.更多还原