【摘要】 本文用免疫组化技术对３３例垂体瘤术后石蜡标本进行了雌激素受体（ＥＲ）和孕激素受体（ＰＲ）检测观察。男１４例，女１９例，年龄２３～６５岁。病理类型，嫌色细胞腺瘤１８例，嗜酸细胞腺瘤７例，混合性腺瘤８例，结果，ＥＲ和ＰＲ的阳性表达率及其含量与性别、年龄无明显相关，但与病理类型明显有关。嫌色细胞腺瘤ＥＲ、ＰＲ阳性率最高，分别为７２．２％、５５．５％；混合性腺瘤分别为２５％、１２．５％；嗜酸细胞腺瘤分别为１４．０％、０．０％。其中嗜酸细胞腺瘤几乎无ＰＲ表达。嫌色细胞腺瘤ＥＲ、ＰＲ平均含量（２．２±１．３３；１．９±１．４５）明显高于嗜酸细胞腺瘤（０．５７±０．７９；０．２９±０．４９）和混合性腺瘤（１．０±１．０７；０．５±０．７６），Ｐ值分别小于０．０１和０．０５。本研究结果提示：①垂体瘤，或至少是部分垂体瘤，可能是雌、孕激素依赖性肿瘤；②雌、孕激素依赖性肿瘤的病理类型大多为嫌色细胞腺瘤（ＰＲＬ腺瘤），少数为混合性腺瘤；③对这部分肿瘤，抗雌、孕激素治疗对阻止肿瘤生长，防止术后复发等可能会有积极作用。更多还原

【Abstract】 Abstract The presence of estradiol receptors(ER)and progesterone receptors(PR)in 33 pituitary adenomas in cluding 18 chromophobe adenoma,7 eosinophile adenoma,and 8 miXed adenoma specimens were investigated with immunohistochemical stainings.The results indicated that there was no correlation between ER and PR Ievels and ages or sexes,but an interesting correlation was observed between ER or PR levels and the histopathological classification,ER and PR levels in chromophobe samples were 2.2±1.33;1.9±1.45 respectively being significantly higher than 0.57±0.79;0.29±0.49 1n eosinophile samples or 1.0±1. 07,0.5±0.76 in mixed samples(P<0.01;P<0. 05).Moreover,in chromophobe specimens,72.2%were ER positive and 55.5%were PR positive. In eosinophile specimens,only 14.0%were ER positive and there were no PR positive resuIts. In mixed specimens,25.0%were ER positive and 12.5%were PR positive. These experimental findings demonstrated that:(1)Human pituitary adenomas,at least some parts of them may be estrogen or progesterone-dependent tumors(2)Many,but no all,estrogen or progesterone-dependent pituitary adenomas might be classified into chromophobe or PRL-secreting adenmas,a few of them were derived from mixed adenomas or PRL/GH-secreting adenomas(3)Selected anti-estrogen or progesterone treatment could be beneficial for such steroid hormone-dependent adenomas to inhibit growth and prevent更多还原