【摘要】 为探讨高渗盐液在烧冲复合伤早期复苏时使用的可能性。用狗３０只，分别致成２５％体表Ⅲ度烧伤复合中度冲击伤。伤后分３组给与不等量的水和钠。伤后第１个２４ｈ，致伤对照组、高渗盐液和晶胶治疗组分别给钠为０．１２３ｍｍｏｌ·ｋｇ^－１·１％ＢＳＡ^－１、０．５００ｍｍｏｌ·ｋｇ^－１·１％ＢＳＡ^－１和０．３０４ｍｍｏｌ·ｋｇ^－１·１％ＢＳＡ－１。３组均于伤后２ｈ开始给液。结果显示，高渗盐液组给液后脉压改善，中心静脉压恢复正常，血液流变的改善优于其他两组；虽总给液量高于对照组，但肺水量较对照明显为低（Ｐ＜０．０５）。血渗各组差别不明显，但两治疗组尿渗明显为高。实验证实，高渗盐液在本实验伤情条件下作复苏用是安全、有效的，未加重肺水肿。文中对高渗盐液的治疗作用及尿渗偏高的机制进行了讨论。更多还原

【Abstract】 Thirty dogs were inflicted with a combined injury of 25%TBSA full thickness burns and moderate blast injury. They were divided into 3 groups. In the 2nd hour after injury, Group l(the control)was infused with 0.123 mmol/L of NaCl/kg/l%BSA, Group 2 with 0.500 mmol/L of NaCl/kg/l%BSA and Group 3 with 0.304 mmol/L of NaCl/kg/l%BSA. It was found that after hypertonic saline(HS)was given,the pulse pressure was increased and the central venous pressure returned gradually to normal.The hemorrheological paramenters were more singificantly improved in HS group than in the other 2 groups. Though the total amount of the infused fluid was greater in HS group than in control group,the lung water content was far less in HS group than in the control(P<0.05).The changes of serum osmotic pressure showed no significant difference among the 3 groups.The findings indicate that HS is an effective and safe agent for the treatment of early severe conbined burn blast injury.It does not aggravate pulmonary edema due to blast injury,The mechanism of the therapeutic effects of HS was discussed.更多还原