节点文献

自发性高血压大鼠组织和心肾缺血组织中Na/Ca2+交换体基因的表达

THE GENE EXPRESSION OF NA+/CA2+EXCHANGER IN SPONTANEOUSLY HYPERTENSIVE RATS AND ISCHEMIC HEART AND KIDNEY

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 王瑜杨鸿张晨晖汤健

【Author】 Institute of Cardiovascular Research Wang Yu, et al

【机构】 北京医科大学心血管研究所

【摘要】 自发性高血压和心肾缺血组织中钙离子水平明显升高。为探讨Na+/Ca2+交换体在其中的作用,我们应用半定量逆转录一多聚酶链反应(RT一PCR)技术,比较了自发性高血压大鼠(SHR)部分组织、缺血时心肌和肾脏与其正常对照组织中Na+/Ca2+交换体mRNA的水平。结果表明,SHR所测组织中Na+/Ca2+交换体mRNA较正常WKY大鼠均降低。结扎48小时引起的缺血肾脏Na+/Ca2+交换体mRNA亦降低。而因异丙基肾上腺素引起的心肌缺血组织中,Na+/Ca2+交换体基因的表达上升。

【Abstract】 ntracellular Ca2+ concentration increases significantly in spontaneously hypertensive rats(SHR ) and is-chemic tissues.In order to evaluate the significance of Na+/Ca2+exchanger in these diseases,we detected the gene expression of Na+/Ca2+ exchanger in some tissues of SHR and ischemic heart and kidney, and compared them with their normal controls. The results showed that in SHR and ligated kidney,Na+/Ca2+ exchanger mRNA level is lower than that in WKY rats and normal kidney. In ischemic heart induced by isoprenaline,this mRNA level increased.

  • 【文献出处】 北京医科大学学报 ,JOURNAL OF BEIJING MEDICAL UNIVERSITY , 编辑部邮箱 ,1994年S1期
  • 【分类号】R394.3
  • 【被引频次】1
  • 【下载频次】43
节点文献中: 

本文链接的文献网络图示:

本文的引文网络