【摘要】 自１９７８年元月至１９９３年４月经血液学确诊的慢性粒细胞白血病急性变（简称慢位急变）患者３６例，其中急粒变者３３例占９１．６６％，急淋变２例，嗜碱性粒细胞变１例。从慢粒转为急变的病程为３个月～１４年，平均４６个月。从急变到死亡者平均６个月，最长者２年。对慢粒的预后因素、急变的前兆监测及治疗进行了讨论。更多还原

【Abstract】 Thirty-six cases of chronic myeloid leukemia (CML) with blast crisis are reported. Among them, 33 cases are with myeloid blast crisis (91. 66%), 2 with lymphoblast crisis, and 1 with basocyte blast crisis. Duration of chronic myeloid leukemia developing into blast crisis was from 3 months to 14 years, with an average of 46 months. During blast crisis, all the patients had fever, malaise, anemia. increased bleeding, general bone pain, progressive enlargement of the spleen and enlargement of the liver. with an increase of leukocyte count in bone marrow and peripheral blood. The patients were treated positively with combined chemotherapy after blast crisis occurred, resulting in death with a mean survival of 6 months, and the longest being of 2 years in a case with lymphoblast crisis. The prognostic factors of chronic myeloid leukemia and the monitoring and treating presymptoms of blast crisis are discussed.更多还原