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丹参和半枝莲对丝裂霉素C诱发小鼠MN和SCE的防护作用
PROTECTIVE EFFECTS OF SALVIA MIL TIORRHIZA AND SCUTELLARIA BARBATA ON GENETIC DAMAGE INDUCED BY MITO-MYCIN C(MMC)
【摘要】 本文以姊妹染色体交换(SCE)和微核(MN)为指标,评价了中药丹参和半枝莲对丝裂霉素C(MMc)诱发小鼠遗传物质损伤的影响,证实了两种中药本身并无诱变作用,提出了丹参,半枝莲具有抗MMC诱发遗传物质损伤的作用。
【Abstract】 By using sister chromatid exchange(SCE)and mieronucleus(MN)as indexes,the protective effects of Salvia miltiorrhiza and Scutellaria on genetic damage induced by MMC was studied in Kunming mice strain.Results showed that the two Chinese medieines themselves can not induce genetic damages but can significantly decrease SCE and MN frequencies induced by MMC,respectively(P<0.01).The results indicated the Chinese medicines could be anti-mut-agenesis.
【关键词】 丹参;
半枝莲;
微核;
姊妹染色单体交换;
遗传物质损伤;
【Key words】 Salvia miltiorrhiza; Scutellaria; Micronucleus; SCE; Genetic damage;
【Key words】 Salvia miltiorrhiza; Scutellaria; Micronucleus; SCE; Genetic damage;
- 【文献出处】 癌变.畸变.突变 ,CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS , 编辑部邮箱 ,1994年06期
- 【分类号】R285.5
- 【被引频次】10
- 【下载频次】71