节点文献

五子衍宗液对雄性大鼠下丘脑单胺类递质、性激素和生育能力的影响

Effect of Wuzi Yanzong Liquid on Hypothalamus,Monoamines, Sexual Hormones and Reproductivity in Male Rats

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 王学美谢竹藩刘庚信钮淑兰

【Author】 Wang Xue-mei, Xie Zhu-fan, et al Institute of Integration of TCM and WM, Beijing Medical University, Beijing (100034)

【机构】 北京医科大学中西医结合研究所北京医科大学中西医结合研究所 北京 100034 博士生北京 100034 导师北京 100034

【摘要】 本研究观察了五子衍宗液对雄性大鼠下丘脑单胺类递质、性激素和生育能力的影响。结果表明,该方可升高老龄大鼠下丘脑去甲肾上腺素(NE)含量,降低5-羟色胺(5-HT)含量和5-HT/多巴胺(DA)比值;升高老龄大鼠血浆睾酮(T)含量,降低雌二醇(E2)/T比值;提高雄性大鼠精子活动度、精子计数和生育能力。

【Abstract】 About 100 male SD rats aged 2, 5, 10, 18 and 24 months (each age group for about 20 rats) wereused in the antisenility experiment. The animals of each age group were further subdivided into twogroups randomly: one group administered with Wuzi Yanzong Liquid (WYL) daily for 5 weeks, andthe other group with normal saline. After treatment, plasma testosterone (T) and estradiol (E2),hypothalamus norepinephrine (NE), dopamine (DA) and serotonin (5-HT) levels were determined. Incomparison with younger groups, the 18 and 24 months old rats administered with saline hadmarkedly lowered plasma T, hypothalamus NE and DA levels, and elevated 5-HT, E2 levels and 5-HT/DA, E2/T ratios; while in the 18 and 24 months rats administered with WYL the abovementioned changes were much less remarkable. Since WYL only raised plasma T level in old rats but not in younger ones, this drug seems to have different action from testosterone preparations. Inanother animal experiment, the reproduction promoting effect of WYL was shown by the increaseof sperm count and motility of sperms in old male rats as well as its reproductive ability.

  • 【文献出处】 中国中西医结合杂志 ,Chinese Journal of Integrated Traditional and Western Medicine , 编辑部邮箱 ,1993年06期
  • 【被引频次】56
  • 【下载频次】121
节点文献中: 

本文链接的文献网络图示:

本文的引文网络