【摘要】 观察58例急性心肌梗塞(AMI)患者发病3周内血浆组织型纤溶酶原激活剂(t-PA)及其抑制剂(PAI)活性的动态变化,比较蝮蛇抗栓酶(SVATE).尿激酶(UK)静脉溶栓治疗和一般常规治疗的作用。结果AMI患者纤溶系统受抑,t-PA和PAI活性分别显著性降低和升高;治疗后有不同程度地恢复,UK组在治疗即刻t-PA和PAI活性出现瞬时最大幅度地增高和降低,随后很快回复入院时水平;2周时t-PA达到正常水平,PAI一直持续在高水平。SVATE组给药即刻t-PA和PAI活性分别升高和降低,此后缓慢改变,2周时t-PA和PAI活性都恢复正常。常规治疗组在观察期间纤溶活性缓慢地改变,给药3周时t-PA和PAI活性尚未达到正常水平。结果说明,溶栓治疗优于常规治疗处理。更多还原

【Abstract】 In the present study, we determined and compared plasma t-PA and PAI activity in 58 AMI patients receiving thrombolytic therapy with UK and snake venom antithrombus enzyme (SVATE) or routine therapy during 3 weeks, and also in 24 healthy subjects.Plasma t-PA activity was decreased and plasma PAI activity increased significantly in patients with AMI as compared to normal controls. UK induced an immediate and transient increase in t-PA and a decrease in PAI activity (P<0.001, respectively),followed by an increase in PAI activity until 21 days. Treatment with SVATE caused an increase in t-PA activity which remained above the normal level at 21 days, and a decrease in PAI activity which reached the normal level by 7 days. Routine therapy resulted in only slow changes in t-PA and PAI activity. These results indicate that UK and SVATE may be effective in the treatment of AMI.更多还原