【摘要】 对新合成的第三代维甲类化合物R8605的抗氧化作用进行研究,发现R8605能明显抑制由Fe²⁺/半胱氨酸和NADPH/维生素C引起的大鼠肝微粒体脂质过氧化,其抑制50%脂质过氧化的浓度(IC₅₀)分别为9.8、17.6和20.3μmol/L。另外,R8605还对黄嘌呤/黄嘌呤氧化酶系统产生的O（?）有一定抑制作用,并提高小鼠肝脏SOD活性。这些都表明其有较强的抗氧化作用。R8605的抗氧化作用对其癌化学预防作用有利,可能是其抗促癌作用的一个重要机理。更多还原

【Abstract】 The anti-oxidative effects of R8605, a compound of the third generation retinoids, have been studied. R8605 exhibited pronounced inhibitory effects on FeSO₄/cysteine and NADPH/vitamin C-induced lipid peroxidation of rat liver microsome as well as on H₂O₂-induced lipid peroxidation of erythrocytes: Their IC₅₀’s were 9.8, 17.6 and 20.3 μmol/L, respectively. R8605 decreased the generation of superoxide anion （O） in a xanthine/xanthine oxidase system and also elevated hepatic superoxide dismutase （SOD） activity in mice. Therefore R8605 shows potent antioxidative effects and this is likely of importance in its chemopreventive actions.更多还原