【摘要】 200名HBV易感者分二组分别接种Amgen公司生产的乙肝酵母基因疫苗(G苗)和Smith公司疫苗(s苗).4年后24.59％的免疫者抗-HBs滴度下降到10mlU/ml以下。抗-HBs保护水平持续时间取决于3针免疫后最高滴度水平。抗-HBs>1000mlU/ml者,4年后G苗仍100％大于10mlU/ml,S苗则为97.6％,而抗-HBs在10～100mIU/ml之间者,4年后皆<10mIU/nl。抗-HBs滴度随时间延长呈指数曲线下降,首次免疫后前24个月几乎下降了全部滴度的80％,以后下降缓慢,抗-HBs滴度水平不同组其回归直线斜率相似,表明抗-HBs滴度下降百分率与最初浓度无关。在此基础上制出标准回归直线,并用做平行线的方法推测个体加强免疫时间。更多还原

【Abstract】 200 Young People were vaccinated with two kinds of Yeast -derived HB vaccines (G, S) and followed up for 4 Years, in order to explore the persistence and the kinetics of anti-HBS and predict the optimal time for revaccination. The result showed that 4 Years after the first vaccination, anti- BHS titres in 24.59％ of vaccinees had fallen below 10mIU/ ml. The persistence of anti-BHS above this value depended on its maximal antbody titres after the third vaccination. In vac- cinees with maximal anti-HBStitres above 1000mIU/ml all re- cipients vac-cinated with vaccine G and 97.6％ of recipients with vaccine S still had titres above 10mIU/ml after 4 Years. whereas no one with initial titres between 10 and 100mIU/ml maintained anti-HBS Soncentrations above 10mIU/ml for longer than 4 years. The anti-HBS titres decreased in the form of exponential curve. The fall in anti-HBS tires was rapid at first, leading to 80％ reduction in the first 24 months after the first vaccination. Subsequently, the decrease was slower. The slopes of linear regression in anti-HBS deferent groups were similar by changing their curves into straight lines. This indi- cated that the percentage of anti-HBS desresase was indepen- den of the initial concen tration of anti-HBS. On the basi sof this, a theoretical linear regression was described and predict- ed the opimal time for an individual reveaccination by drawing a paralled line with theoretical line.更多还原