【摘要】 本文研究了氧化苦参碱对淋巴细胞胞浆游离钙、钙摄取功能、cAMP 及cGMP 水平的影响。结果表明:氧化苦参碱可使淋巴细胞浆游离钙水平上升,其钙离子来源于细胞内储存钙的释放。另外,氧化苦参碱可使PHA 活化的人扁桃体淋巴细胞的cAMP 水平降低。我们推测它可能通过某种方式和细胞膜发生作用,从而影响细胞内钙和cAMP 的水平,进而影响细胞功能。更多还原

【Abstract】 We studied the effects of oxymatine,an alkaloid from Sophra Flavesens Ait,on human andmouse’s lymphocytes’ cytoplasmic free calcium,calium uptaking,cAMP & cGMP level.Theresults show that:(1).Oxymatrine can raise the cytoplasmic free calcium.(2).It can also de-crease the cAMP level of PHA preactivated human tonsillar lymphocytes (3).It has no effect oncGMP level of lymphocyte.(4).It has no effect on the calcium uptaking.Combined with ourprevious report,we think that oxymatrine may influence cells’ [Ca++] and cAMP level via af-fecting cell membrane.更多还原