【摘要】 本文将16只雄性日本大耳白兔制成动脉粥样硬化模型,在X线透视下行狭窄处球囊扩张术,并于术前及术后不同时间取材,按常规方法制作超薄切片做透射电镜观察.扩张前的标本呈现典型的动脉粥样硬化改变;扩张即刻可见内皮剥脱、内弹力膜断裂及斑块碎裂伴有血小板的粘附、聚集;扩张后1周、2周及6周的变化是以平滑肌细胞增生为主的内膜增厚,提示血管损伤、血小板沉积和平滑肌细胞增生在血管成形术后再狭窄的形成中起着重要作用,且反应了血管损伤、修复这一连续过程.更多还原

【Abstract】 Atherosclerotic stenosis model was es-tablished in 16 male Japanese white rabbits by denuding the endothelium and feeding with hypercholesterol diet. Transluminal angioplasty was performed 3 months later. The animals were killed at 1 hour, 1 week , 2 weeks and 6 weeks after dilatation for ex-amination by transmission electron micro-scope. Typical atherosclerotic Lessions were seen before dilatation. Plaque disrup-tion , endothelium denudation, intimal elas-tic lamina rupture and cracks in the intima and media were discovered , accompanied by platelets adhesion and aggregation immedi-ately after the procedure. But in the les-sions of 1 week , 2 weeks and 6 weeks the main mophologic changes were intimal hy-perplasia dominated by smooth muscle cell-s. Our results suggested that injury, platelets adhesion and aggregation and smooth muscle cells proliferation all play the important role in restenosis after angio-plasty.更多还原