【摘要】 观察了一种醛糖还原酶抑制剂(ICI 128436)对小鼠胰岛体外培养时山梨醇代谢的影响情况。小鼠胰岛培养72小时后,酶抑制剂处理过的胰岛山梨醇水平较对照组显著降低。结果表明小鼠胰岛可以合成山梨醇,其生成水平与醛糖还原酶的活性密切有关。更多还原

【Abstract】 The effect of ICI 128436, an aldose reductase inhibitor on the sorbitol metabolism in the mouse pancreatic islets during in vitro culture was observed. After culture for 72 hours, the levels of the sorbitol from the islets treated with the aldose reductase inhibitor were significantly decreased in comparison with those from the control islets. It denotes that the levels of sorbitolgenera-tion are closely related to the activity of aldose reductase, although the sorbitol may be synthctized in the pancreatic islets.更多还原