【摘要】 485例上海和美国旧金山中国人中6个基因(或基因区)的限制性内切酶片段长度多态性(RFLP)与非胰岛素依赖型糖尿病(NIDDM)的关联情况研究见到:(1)胰岛素受体(INSR)、载脂蛋白B(Apo B)、载脂蛋白A1(Apo A1)3个基因与中国人NIDDM发病有一定关联;(2)RFLP频率有明显的种族间差异,而且同一种民族在不同地区人群中亦有差异;(3)RFLP摹因型对糖尿病的临床表现型有影响,糖尿病与非糖尿病的肥胖在病因学上并不相同,尚见到NIDDM伴脂质代谢紊乱。更多还原

【Abstract】 A study of the association of six genes or gene region restriction fragment lengh polymorphism (RFLP) with non-insulin-dependent diabetes mellitus(NIDDM) in 485 Chinese of Han origin, who lived in Shanghai, China and San Francisco, USA, showed: 1) There was an association of three genes, INSR, Apo B, Apo A1, with NIDDM. The frequencies of hap-Jotype XIR3K.2 and X2R2K2 in INSR gene significantly decreased in NIDDM (Pc<0.05 and <0.006 respectively); the alleles and genotype frequencies of Apo B gene RFLP in lean/normal weight (BMI<24) NIDDM showed significant difference from the non-diabetic (ND) group (P<0.025 and 0.05 respectively); and Mspl RFLP of Apo A, was associated with obese / overweight NIDDM, which presented a significant increase in frequency of Ml allele in Mspl / Apo A1 RFLP in NIDDM (X2 = 10.03, P<0.001). 2) Our results not only revealed obvious ethnic differences of RFLP frequency, but also a geographical variation in Chinese. 3) The RFLP genotype exerted prominent effects on the development of NIDDM phenotype and the disturbance of lipid metabolism of NIDDM. The methods of molecular genetic study of diabetes were briefly discussed. The observed and control groups should be matched in ancestor origin in clinical investigation.更多还原