【摘要】 1990年6月至1991年6月选择中晚期食管癌64例,随机入卡铂加放疗组和单纯放疗组,两组放疗剂量为60～70Gy/6～7周,卡铂加放疗组,放疗第1、4周同时用卡铂,两周期总量为1000mg。卡铂加放疗组近期疗效明显优于单纯放疗组,1年生存率分别为65.6％(21/32)和40.6％(13/32),有显著差异,显示卡铂与放疗有明显协同作用。更多还原

【Abstract】 Sixty-four patients with moderately and advanced, esophageal carcinoma treated form 1990 to 1991 were randomized into 2 groups, radiotherapy only group (R) and radiotherapy plus carboplatin group (R+C). A total dose of. 60-70 Gy/ 6-7wk was used in either group. In the R+C group, 1000mg of carboplatin was given in the first and fourth weeks during radiotherapy. The results showed that the improvement in deglutition as well as the 1- year survival rate were better in the R+C group as compared with that of R group (65.6%-21/32 vs 40. 6%-13/32). The difference was significant statistically. The authors believe that combination of carboplatin with radiotherapy is preferred for esophageal carcinoma.更多还原