【摘要】 对44例创伤性脑水肿患者根据GCS计分结果测定颅内压(ICP)、磷酸肌酸激酶(CK)及脑干听觉诱发电位(BAEP)检查,以研究GCS、ICP、CK与BAEP间的关系。发现轻重组的ICP在4kPa以上的比率显然不同(P<0.05),CK也有显著差别(P<0.05),ICP在4kPa上下的BAEP异常率分别为77.78%和38.46%(P<0.05),BAEP正常、轻度异常和重度异常或缺失,两大组的CK值有极显著差异(P<0.001)。表明:当ICP≥4kPa时CK值明显增高,BAEP异常率显著增加,ICP、CK、BAEP和创伤性脑水肿严重程度呈同步改变,说明神经生理BAEP的变化,间接反映脑外伤后生物物理和生物化学的改变有内在关系。更多还原

【Abstract】 The relation between ICP, CK and BAEP was studied in 44 cases with traumatic brain edema admitted to our department from June 1990 to Feb 1991. There were 30 males and 14 females, aged from 9 to 67 years. The result showed that the abnormal BAEP could reflect the severity of cerebral edema in acute head injury and was related to intracranial pressure (ICP) and serum creatine kinase levels (CK). When ICP≥4kPa(30mmHg), the abnormal change in BAEP happened more obviously compared to the controls (P<0. 05), and serum CK levels also elevated remarkably. While in the patients with ICP over and below 4 kPa (30 mmHg), the rate of abnormal BAEP were 38. 46%, and 77.78%, respectively (P<0. 05). The serum CK level in the group of normal or moderate abnormality of BAEP was significantly different from that in the group of severe abnormality or lack of BAEP (272.85u/L, 705. 3u/L; P<0. 05). With the recovery of ICP after treatment, the BAEP was normalized and serum CK levels also decreased. The reults illustrate that BAEP may denote indirectly the relevant biochemical and biophysical changes following the traumatic brain edema. According to our observation, the BAEP examination is important in traumatic brain edema.更多还原