【摘要】 本文报告了以白氨酸-谷氨酸苄酯共聚物为基体的18-甲基炔诺酮缓释药物微球的制备方法,讨论了聚合物粘度、有机相/水相比例、分散剂液溶度、搅拌速度等对药球球径的影响。本文还对4种不同比例的氨基酸共聚物制备的药物微球进行了体外释药实验,研究表明,释药速率近似与释药时间的1/2次方成反比。根据Higuchi方程式,我们计算了扩散系数。释药速率主要取决于缓释微球的球径和扩散系数。更多还原

【Abstract】 Norgestrel-containing microspheres basedon leucine-benzyl glutamate copolymers wereprepared by solvent-evaporation method. Inthis process, a decrease in polymer viscosity oran increase in organic phase/water phase ra-tio, concentration of gelatin aqueous solutionand initial stirring rate could lead to reducethe diameters of the microspheres. In vitrodrug-releasing behaviour of these micro-spheres was approximately agreed with theHiguchi equation, that is, the drug-releasingrates were inversely proportional to the squareroot of their drug-releasing time. The diffusioncostants of microspheres were calculated anddepended on chemical structures of aminoacids copolymers. The larger the diffusion con-stant and the less the diameter of micro-spheres, the faster the drug was released fromthe microspheres.更多还原